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web2py - Python Web Framework
web2py is a full-stack framework for rapid development of fast, scalable, secure and portable database-driven web-based applications. This framework is based on Model-View-Controller design and it has support to Server-side form validation and postbacks. It has the ability to generate forms from database tables and it includes an extensive set of validators.
Tryton - General Purpose Application Platform
The core of Tryton (also called Tryton kernel) provides all the necessary functionalities for a complete application framework: data persistence, extensive modularity, users management (authentication, fine grained control for data access, handling of concurrent access of resources), workflow and report engines, web services and internationalisation. Thus constituting a complete application platform which can be used for any relevant purpose.
karacos - Web platform engine
KaraCos is a Python Framework which enables easy, quick, and clean web applications development. CouchDB, a no-SQL database for data storage. Its basic application is a CMS. Its structure is a tree of Nodes and each Node can contain Nodes or files (leafs).