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web2py is a full-stack framework for rapid development of fast, scalable, secure and portable database-driven web-based applications. This framework is based on Model-View-Controller design and it has support to Server-side form validation and postbacks. It has the ability to generate forms from database tables and it includes an extensive set of validators.
The core of Tryton (also called Tryton kernel) provides all the necessary functionalities for a complete application framework: data persistence, extensive modularity, users management (authentication, fine grained control for data access, handling of concurrent access of resources), workflow and report engines, web services and internationalisation. Thus constituting a complete application platform which can be used for any relevant purpose.
KaraCos is a Python Framework which enables easy, quick, and clean web applications development. CouchDB, a no-SQL database for data storage. Its basic application is a CMS. Its structure is a tree of Nodes and each Node can contain Nodes or files (leafs).